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KMID : 1189420030160020119
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2003 Volume.16 No. 2 p.119 ~ p.137
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The Immunosuppressive Effect of Younggaechulgam-tang through Inhibition of Nuclear Translocation of Transcription Factor
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Hong Chul-Hee
Kim Nam-Kwen
Lee Soo-Hyeong
Du In-Sun
Hwang Choong-Yeon
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Abstract
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Younggaechulgam-tang has been used for treating skin diseases. In this study, I investigated the immunosuppressive effect of Younggaechul-tang in the human T cell line MOLT-4 cells. MOLT-4 cells were stimulated with the phytohemagglutinin (PHA) and phorbol 12-myristate 13-acetate (PMA) + A23187. The secretion appeared to be greater when cells were stimulated with PHA than with PMA + A23187. Younggaechulgam-tang had no affect proliferation stimulated by PHA. I showed that IL-2 secretion and expression by PHA stimulated MOLT-4 cells were inhibited by Younggaechugam-tang treatment. Maximal inhibition rate of IL-2, TNFα secretion was 80% and 30%, respectively. Younggaechulgam-tang also inhibited nuclear translocation of p65 subunit of nuclear factor-kB and nuclear factor of activated T cells (NFAT). In conclusion, these results suggest that Younggaechulgam-tang may contribute to the immunosuppressive oriental drug clinically.
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KEYWORD
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